Thymosin beta-4 fragment8 min read

TB-500: What It Is and What It Does

The active piece of a natural repair protein — studied for wound healing and recovery. Below: what TB-500 is, what it does in plain terms, and the published studies — for laboratory research use only.

VNG Research TeamJuly 15, 2026
Class
Thymosin beta-4 fragment
Published studies cited
10
Literature span
2007–2023

For research & educational purposes only. This article is a neutral, procedural reference for laboratory / in-vitro research handling — not medical advice or a usage recommendation. These materials are not for human or animal consumption.

On this page

What TB-500 is

TB-500 is a lab-made piece of a natural protein your body already uses, called thymosin beta-4. It is supplied as an analytical-grade reference material for laboratory research.

What it does — in plain terms

Your body keeps thymosin beta-4 on hand for building and repair jobs — it helps move repair cells to where they're needed and encourages new blood vessels to form. TB-500 is the active fragment of that protein. So research looks at it for wound healing and recovery: basically helping the body's 'construction crew' cells reach an injury and start rebuilding. It's frequently studied alongside BPC-157 for that reason.

Here's where TB-500 actually shows up in the published research:

  • Wound healing
  • Cell migration (getting repair cells to an injury)
  • New blood-vessel growth
  • Muscle and tissue recovery

Plain-language explanations describe what researchers study — not what any product does for a person, and not medical advice. Every material here is sold for laboratory research use only and is not for human or animal use.

Reconstitution reference

Standard laboratory reconstitution volumes for TB-500, from the VNG Reconstitution Sheet. See the full reconstitution guide for the method and concentration math.

ProductVialBacteriostatic waterResulting concentration
TB-50010 mg2 mL5 mg/mL
GLOW (GHK-Cu + BPC-157 + TB-500)70 mg3 mL~23.3 mg/mL
KLOW (BPC-157 + GHK-Cu + TB-500 + KPV)80 mg3 mL~26.7 mg/mL

Published research

A selection of peer-reviewed and clinical literature indexed on PubMed. Provided so qualified researchers can locate the primary sources — inclusion here is not a claim about any product or outcome.

  1. Peer-reviewed studyAnnals of the New York Academy of Sciences · 2007

    Beta-thymosins — overview

    View on PubMed
  2. Peer-reviewed studyInternational immunopharmacology · 2023

    Thymosin beta-4 in regenerative therapy research

    View on PubMed
  3. Peer-reviewed studyExpert opinion on biological therapy · 2018

    Thymosin beta-4 and the eye

    View on PubMed
  4. Peer-reviewed studyCurrent medicinal chemistry · 2020

    Thymosin beta-4 and tissue repair in heart injury

    View on PubMed
  5. Lab / formulation studyVitamins and hormones · 2016

    Thymosin beta-4 and liver (hepatic stellate) cells

    View on PubMed
  6. Peer-reviewed studyAnnals of the New York Academy of Sciences · 2010

    Thymosin beta-4 tissue-repair peptide — animal studies

    View on PubMed
  7. Animal-model studyInternational immunopharmacology · 2023

    Thymosin beta-4 and bacterial keratitis

    View on PubMed
  8. Animal-model studyKidney international · 2016

    Thymosin beta-4 and kidney (glomerular) disease

    View on PubMed
  9. Peer-reviewed studyBrain : a journal of neurology · 2014

    Thymosin beta-4 in glioblastoma research

    View on PubMed
  10. Animal-model studyInternational immunopharmacology · 2023

    Thymosin beta-4 and middle-ear healing

    View on PubMed

References & resources

Related reference materials

VNG Research Team

VNG Labs supplies analytical-grade reference materials with lot-matched Certificates of Analysis. Our write-ups are neutral, source-cited references for qualified and independent researchers.

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Research use only. Not for human consumption or veterinary use. Sold exclusively to qualified researchers for in vitro and laboratory research. These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Refrigerate upon receipt. Keep in dark environment.