Coenzyme8 min read

NAD+: What It Is and What It Does

A helper molecule every cell uses to make energy — central to aging and metabolism research. Below: what NAD+ is, what it does in plain terms, and the published studies — for laboratory research use only.

VNG Research TeamJuly 15, 2026
Class
Coenzyme
Published studies cited
10
Literature span
2014–2025

For research & educational purposes only. This article is a neutral, procedural reference for laboratory / in-vitro research handling — not medical advice or a usage recommendation. These materials are not for human or animal consumption.

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What NAD+ is

NAD+ (nicotinamide adenine dinucleotide) is not a peptide — it's a coenzyme, a helper molecule that every cell uses to produce energy. It is supplied as an analytical-grade reference material for laboratory research.

What it does — in plain terms

NAD+ works like a rechargeable battery your cells pass around to get chemical work done, especially turning food into usable energy. Levels naturally decline as we age, which is why it's a huge topic in aging research. Labs study how NAD+ powers energy production, helps repair DNA, and switches on a family of 'maintenance' proteins called sirtuins that are linked to healthy aging.

Here's where NAD+ actually shows up in the published research:

  • Cellular energy production
  • DNA repair
  • Sirtuin ('longevity gene') activity
  • Aging and metabolism models

Plain-language explanations describe what researchers study — not what any product does for a person, and not medical advice. Every material here is sold for laboratory research use only and is not for human or animal use.

Reconstitution reference

Standard laboratory reconstitution volumes for NAD+, from the VNG Reconstitution Sheet. See the full reconstitution guide for the method and concentration math.

ProductVialBacteriostatic waterResulting concentration
NAD+500 mg2.5 mL200 mg/mL
NAD+1000 mg5 mL200 mg/mL

Published research

A selection of peer-reviewed and clinical literature indexed on PubMed. Provided so qualified researchers can locate the primary sources — inclusion here is not a claim about any product or outcome.

  1. Peer-reviewed reviewEndocrine reviews · 2023

    NAD+ in aging biology — review

    View on PubMed
  2. Lab / formulation studyCells · 2024

    NAD+ and skin aging — pharmacological study

    View on PubMed
  3. Peer-reviewed studyTrends in cell biology · 2014

    NAD+ and sirtuins in aging

    View on PubMed
  4. Mechanistic studyScience (New York, N.Y.) · 2015

    NAD+ in aging, metabolism & neurodegeneration

    View on PubMed
  5. Human clinical studyAdvances in nutrition (Bethesda, Md.) · 2023

    NMN safety & anti-aging — human clinical trials

    View on PubMed
  6. Lab / formulation studyNature cancer · 2025

    NAD+ decline and CAR-T cell function

    View on PubMed
  7. Mechanistic studyNature reviews. Molecular cell biology · 2021

    NAD+ metabolism in cellular ageing

    View on PubMed
  8. Peer-reviewed studyJournal of advanced research · 2022

    NMN as an anti-aging product — promises & safety

    View on PubMed
  9. Mechanistic studyAging cell · 2024

    NAD+ metabolism, senescence & aging

    View on PubMed
  10. Mechanistic studyAntioxidants & redox signaling · 2023

    NAD+ signaling in neurological disorders

    View on PubMed

References & resources

Related reference materials

VNG Research Team

VNG Labs supplies analytical-grade reference materials with lot-matched Certificates of Analysis. Our write-ups are neutral, source-cited references for qualified and independent researchers.

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Research use only. Not for human consumption or veterinary use. Sold exclusively to qualified researchers for in vitro and laboratory research. These statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Refrigerate upon receipt. Keep in dark environment.